Salmol Syrup Mechanism of Action

Pharmacology: Pharmacodynamics: Salbutamol is sympathomimetic agent that stimulate beta₂-adrenergic receptors. Salbutamol relaxes the bronchial smooth muscle by action on with little effect on heart rate.
Pharmacokinetics: Salbutamol sulfate is rapidly and well-absorbed following oral administration. Peak plasma concentrations occur within about 2 hours following administration of oral solution. Salbutamol crosses the blood-brain barrier, reaching the brain at concentrations that are approximately 5% of plasma concentrations. Salbutamol apparently crosses the placenta, but it is not known whether salbutamol is distributed into milk. After oral administration, the half-life of salbutamol is 5 - 6 hours. Salbutamol is extensively metabolized in the liver, mainly to salbutamol 4'-O-sulfate which has little effect or no β-adrenergic blocking effect. Salbutamol and its metabolites are rapidly excreted in urine and feces. About 75% of single dose oral administration is excreted in urine within 72 hours, mainly as the major metabolite; about 4% of the dose is excreted in feces.